29 April 2009
Short-term clinical disease progression in HIV-infected patients receiving combination antiretroviral therapy: results from the TREAT Asia HIV observational database.
Srasuebkul P et al.
Clin Infect Dis 2009;48:940–50.
• The aim of this study was to develop, using simple clinical data, predictive short-term risk equations for AIDS or death in Asian HIV patients.
• Three different models were developed: a clinical model, a CD4 cell count model and a CD4 cell count and HIV RNA level model.
• Conclusions: These are simple models enabling widespread clinical use to identify patients at high risk of AIDS or death in Asia, the Pacific region and resource-poor settings.
Link
29 April 2009
Editorial Use of risk equations for predicting disease progression in HIV infection.
Mocroft A, Lundgren JD.
Clin Infect Dis 2009;48:951–3.
• The aim of this study was to develop, using simple clinical data, predictive short-term risk equations for AIDS or death in Asian HIV patients.
• Three different models were developed: a clinical model, a CD4 cell count model and a CD4 cell count and HIV RNA level model.
• Conclusions: These are simple models enabling widespread clinical use to identify patients at high risk of AIDS or death in Asia, the Pacific region and resource-poor settings.
Link
05 June 2009
HIV-associated behaviors among injecting-drug users — 23 cities, United States, May 2005–February 2006.
2009, Vol. 58
• This study reports a CDC analysis of data from the National HIV Behavioral Surveillance System (NHBS) collected from May 2005 to February 2006 to assess HIV-associated behaviours among IDUs at risk for HIV infection.
• During this period, 31.8% of participating IDUs reported sharing syringes, 62.6% had unprotected vaginal sex, 71.5% had been tested for HIV and 27.4% had participated in an HIV behavioural intervention.
• Conclusion: The data can help guide prevention services tailored to IDUs at risk for HIV infection and other blood-borne or sexually transmitted infections.
Link
22 October 2009
Alcohol use and antiretroviral adherence: review and meta-analysis.
Hendershot CS, Stoner SA, Pantalone DW et al
J Acquir Immune Defic Syndr 2009;52:180–202.
• This meta-analysis evaluated the association between alcohol use and ARV adherence.
• Forty studies including >25,000 participants were identified from literature searches.
• Alcohol users were approximately 50–60% as likely to be adherent [OR: 0.548; 95% CI: 0.490–0.612] as non-drinkers or those who drank less.
• Effect sizes for problem drinking were greater (OR: 0.474; 95% CI: 0.408–0.550) than those for any or global drinking (OR: 0.604; 95% CI: 0.531–0.687).
• Conclusions: The results support a significant and reliable association between alcohol use and medication non-adherence.
Link
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